20.02.2025, 10:15
– Raum 0.12 in Haus 9
Forschungsseminar Differentialgeometrie
Kähler and quaternion-Kähler manifolds of non-negative curvature
Uwe Semmelmann (Stuttgart)
Jane Knöchel (InSilicoTrials, Sweden)
Quantitative system pharmacology models (QSP) are a subset of mathematical models focused on drug pharmacology. They integrate datasets from diverse studies, contexts, and spatiotemporal scales into a mathematical framework, providing a snapshot of the current understanding of the underlying system. Due to the complexity of these systems, QSP models often include a large number of molecular species and reactions, resulting in the "curse of dimensionality." This complexity can make the models difficult to use in statistical analyses of large datasets. In this talk, we introduce a model reduction technique that preserves biological understanding while quantifying the relevant components of the system for a given input-response pair. The efficacy of this methodology is demonstrated on both small and large-scale QSP models.