Publikationen

2019 | Comment on Jaki et al., A proposal for a new PhD level curriculum on quantitative methods for drug development. Pharmaceutical Statistics 17 (5):593–606, Sep/Oct 2018, DOI: 10.1002/pst.1873 | A. Krause, C. Kloft, W. Huisinga, M. Karlsson, J. Pinheiro, R. Bies, J. Rogers, F. Mentré, B.J. Musser, ASA Special Interest Group on Statistics and Pharmacometrics/ASA Special Interest Group on Statistics and Pharmacometrics (SIG SxP)
Zeitschrift: Pharmaceutical Statistics Link zur Publikation

2019 | The circadian rhythm of corticosteroid-binding globulin has little impact on cortisol exposure after hydrocortisone dosing | J. Melin, N. Hartung, Z.P. Parra-Guillen, M.J. Whitaker, R.J. Ross, C. Kloft
Zeitschrift: Clinical Endocrinology Link zur Publikation

2018 | Understanding and reducing complex systems pharmacology models based on a novel input-response index | J. Knöchel, C. Kloft, W. Huisinga
Zeitschrift: J Pharmacokinet Pharmacodyn Seiten: 139-157 Band: 45 Link zur Publikation , Suppl Material (Matlab code)

2018 | Stochastic and Deterministic Models for the Metastatic Emission Process: Formalisms and Crosslinks | C. Gomez, N. Hartung
Reihe: Methods Mol. Biol. Buchtitel: von Stechow L. (eds) Cancer Systems Biology Seiten: 193-224 Band: 1711 Link zur Publikation

2017 | Towards toxicokinetic modelling of aluminium exposure from adjuvants in medicinal products | K. Weisser, S. Stübler, W. Matheis, W. Huisinga
Zeitschrift: Regul Toxicol Pharmacol Seiten: 310-321 Band: 88 Link zur Publikation

2017 | Study of metastatic kinetics in metastatic melanoma treated with B-RAF inhibitors: Introducing mathematical modelling of kinetics into the therapeutic decision | N. Hartung, C.T. Huynh, C. Gaudy-Marqueste, A. Flavian, N. Malissen, M.A. Richard-Lallemand, F. Hubert, J.-J. Grob
Zeitschrift: PLoS ONE Band: 12(5) Link zur Publikation , e017608074

2017 | Model Description Language (MDL): A Standard for Modelling and Simulation | M. Smith, S. Moodie, R. Bizzotto, E. Blaudez, E. Borella, L. Carrara, P. Chan, M. Chenel, E. Comets, R. Gieschke, K. Harling, L. Harnisch, N. Hartung, A. Hooker, M. Karlsson, R. Kaye, C. Kloft, N. Kokash, M. Lavielle, G. Lestini, P. Magni, A. Mari, F. Men
Zeitschrift: CPT: Pharmacometrics & Systems Pharmacology Link zur Publikation , doi:10.1002/psp4.12222

2017 | Predicting Cortisol Exposure from Paediatric Hydrocortisone Formulation Using a Semi-Mechanistic Pharmacokinetic Model Established in Healthy Adults | J. Melin, Z.P. Parra-Guillen, N. Hartung, W. Huisinga, R.J. Ross, M.J. Whitaker, C. Kloft
Zeitschrift: Clin Pharmacokinet. Verlag: Springer Link zur Publikation , doi: 10.1007/s40262-017-0575-8

2017 | Magnitude of Increased Infliximab Clearance Imposed by Anti-infliximab Antibodies in Crohn's Disease Is Determined by Their Concentration | H. Edlund, C. Steenholdt, M.A. Ainsworth, E. Goebgen, J. Brynskov, O.Ø. Thomsen, W. Huisinga, C. Kloft
Zeitschrift: AAPS J Seiten: 223-233 Band: 19(1) Link zur Publikation

2017 | Translational Pharmacometric Evaluation of Typical Antibiotic Broad-Spectrum Combination Therapies Against Staphylococcus Aureus Exploiting In Vitro Information | S. Wicha, W. Huisinga, C. Kloft
Zeitschrift: CPT Pharmacometrics Syst Pharmacol Seiten: 512-522 Band: 6(8) Link zur Publikation

2017 | Impact of altered endogenous IgG on unspecific mAb clearance | S. Fuhrmann, C. Kloft, W. Huisinga
Zeitschrift: J Pharmacokinet Pharmacodyn Seiten: 351-374 Band: 44 Link zur Publikation , Suppl Material (Matlab code)

2017 | Semimechanistic Bone Marrow Exhaustion Pharmacokinetic/Pharmacodynamic Model for Chemotherapy-Induced Cumulative Neutropenia | A. Henrich A, M. Jörger, S. Kraff, U. Jaehde U, W. Huisinga, C. Kloft, Z.P. Parra-Guillen
Zeitschrift: J Pharmacol Exp Ther Seiten: 347-358 Band: 362(2) Link zur Publikation

2017 | Role of renal function in risk assessment of target non-attainment after standard dosing of meropenem in critically ill patients: A prospective observational study | L. Ehmann, M. Zoller, I. K. Minichmayr, C. Scharf, B. Maier, M. V. Schmitt, N. Hartung, W. Huisinga, M. Vogeser, L. Frey, J. Zander, C. Kloft
Zeitschrift: Critical Care Seiten: 263 Band: 21 Link zur Publikation

2017 | Paracrine and autocrine regulation of gene expression by Wnt-inhibitor Dickkopf in wild-type and mutant hepatocytes | N. Hartung, U. Benary, J. Wolf, B. Kofahl
Zeitschrift: BMC Systems Biology Seiten: 98 Band: 11 Link zur Publikation

2015 | Target driven pharmacokinetics of biopharmaceutics | W. Huisinga, S. Fuhrmann, L. Fronton, B.F. Krippendorff
Verlag: Wiley Buchtitel: 'Therapeutic Proteins – ADME and translational PK/PD in discovery and development', H. Zhou and F.-P. Theil (Eds.), ISBN 978-1-118-89864-2 Link zur Publikation

2014 | Quantifying the degree of persistence in random amoeboid motion based on the Hurst exponent of fractional Brownian motion | N. Makarava, S. Menz, M. Theves, W. Huisinga, C. Beta, M. Holschneider
Zeitschrift: Phys Rev E 90, 042703 Link zur Publikation

2014 | Meta-analysis for diagnostic accuracy studies: A new statistical model using beta-binomial distributions and bivariate copulas | O. Kuß, A. Hoyer, A. Solms
Zeitschrift: Statistics in Medicine Seiten: 17-30 Band: 33 Link zur Publikation

2014 | Monoclonal antibody disposition: a simplified PBPK model and its implications for the derivation and interpretation of classical compartment models | L. Fronton, S. Pilari, W. Huisinga
Zeitschrift: J. Pharmacokinet. Pharmacodyn. Seiten: 87-107 Band: 41 Link zur Publikation , Suppl Material (Matlab code)

2014 | Estimating HIV-1 Fitness Characteristics from Cross-sectional Genotype Data | S. Gopalakrishnan, H. Montazeri, S. Menz, N. Beerenwinkel, W. Huisinga
Zeitschrift: PLoS Computational Biology Seiten: 1-14 Band: 10 Link zur Publikation , e1003886, Suppl Material (R and Matlab code)

2012 | Predicting the F(ab)-mediated effect of monoclonal antibodies in vivo by combining cell-level kinetic and pharmacokinetic modelling | B.-F. Krippendorff, D. A. Oyarzún, W. Huisinga
Zeitschrift: J. Pharmacokinet. Pharmacodyn. Seiten: 125-139 Band: 39 Link zur Publikation

2012 | Modeling inter-individual variability in physiologically-based pharmacokinetics and its link to mechanistic covariate modeling | W. Huisinga, A. Solms, L. Fronton, S. Pilari
Zeitschrift: CPT: Pharmacometrics & Systems Pharmacology Band: 1 Link zur Publikation , Suppl Material (Data and Matlab code)

2012 | Hybrid stochastic-deterministic solution of the chemical master equation | S. Menz, J.C. Latorre, C. Schütte, W. Huisinga
Zeitschrift: SIAM Multiscale Modelling and Simulation Seiten: 1232-1262 Band: 10 Link zur Publikation

2011 | Intra-aortic balloon pump counterpulsation (IABP) for myocardial infarction complicated by cardiogenic shock | S. Unverzagt, M.-T. Machemer, A. Solms, H. Thiele, D. Burkhoff, M. Seyfarth, A. de Waha, E. Magnus Ohman, Michael Buerke, Johannes Haerting, Karl Werdan, Roland Prondzinsky
Zeitschrift: Cochrane Database of Systematic Reviews 6, CD007398 Link zur Publikation

2011 | Gestational Influences on the Pharmacokinetics of Gestagenic Drugs: A Combined In Silico, In Vitro and In Vivo Analysis | S. Pilari, C. Preusse, W. Huisinga
Zeitschrift: Eur J Pharm Sci. Seiten: 318-331 Band: 42 Link zur Publikation

2011 | Logarithmic convergence rate of Levenberg_Marquardt method with application to an inverse potential problem | C. Böckmann, A. Kammanee, H.-A. Braunß
Zeitschrift: Journal of Inverse and III-Posed Problems Seiten: 345-367 Band: 19 Link zur Publikation

2011 | Error-Controlled Global Sensitivity Analysis of Ordinary Differential Equations | A. Y. Weiße, W. Huisinga
Zeitschrift: J. Comput. Phys. Seiten: 6824-6842 Band: 230 Link zur Publikation , Suppl Material (zip)

2011 | HIV Quasispecies Dynamics during Pro-Active Treatment Switching: Impact on Multi-Drug Resistance and Resistance Archiving in Latent Reservoirs | M. von Kleist, S. Menz, H. Stocker, K. Arasteh, C. Schütte, W. Huisinga
Zeitschrift: PLoS ONE Band: 6 Link zur Publikation , e18204

2010 | Drug-Class Specific Impact of Antivirals on the Reproductive Capacity of HIV | M. von Kleist, S. Menz, W. Huisinga
Zeitschrift: PLoS Comput Biol Band: 6(3) Link zur Publikation , e1000720

2010 | Quantifying uncertainty, variability and likelihood for ordinary differential equation models | A. Y. Weiße, R. Middleton, W. Huisinga
Zeitschrift: BMC Systems Biology Band: 4 Link zur Publikation

2010 | Lumping of Physiologically Based Pharmacokinetic Models and a Mechanistic Derivation of Classical Compartmental Models | S. Pilari, W. Huisinga
Zeitschrift: J. Pharmacokinet. Pharmacodyn. Seiten: 365-405 Band: 37 Link zur Publikation

2010 | Eine gute Dosis Mathematik - Modellbasierte Arzneimittelentwicklung am Beispiel therapeutischer Proteine | W. Huisinga, B.-F. Krippendorff
Zeitschrift: Systembiologie.de, Ausg. 02, December 2010 Link zur Publikation

2009 | Ligand accumulation counteracts therapeutic inhibition of receptor systems | B.-F. Krippendorff, D. Oyarzun and W. Huisinga
Zeitschrift: Proceedings of Foundations of Systems Biology in Engeneering, FOSBE Seiten: 173-176 Link zur Publikation

2009 | Using math to optimize medication | W. Huisinga
Zeitschrift: NUI Maynooth Research Magazine, Vol. 1, January 2009 Link zur Publikation

2009 | Pharmacokinetic-Pharmacodynamic relationship of NRTIs and its connection to viral escape: An example based on Zidovudine | M. von Kleist, and W. Huisinga
Zeitschrift: Eur J Pharm Sci. Seiten: 532-543 Band: 36 Link zur Publikation

2009 | Mechanism-based Inhibition: Deriving KI and kinact directly from Time-Dependent IC50 Values | B.-F. Krippendorff, R. Neuhaus, P. Lienau, A. Reichel, W. Huisinga
Zeitschrift: J Biomol Screen. Seiten: 913-923 Band: 14 Link zur Publikation , Suppl Material

2009 | Nonlinear Pharmacokinetics of Therapeutic Proteins Resulting from Receptor Mediated Endocytosis | B.-F. Krippendorff, K. Küster, C. Kloft, W. Huisinga
Zeitschrift: J. Pharmacokinet. Pharmacodyn. Seiten: 239-260 Band: 36 Link zur Publikation , Suppl Material

2009 | Retention of gene products in syncytial spermatids promotes non-Mendelian inheritance as revealed by the t-complex-responder | N. Véron, H. Bauer, A. Y. Weiße, G. Lüder, M. Werber, and B. G. Herrmann
Zeitschrift: Genes & Development Seiten: 2705-10 Band: 23 Link zur Publikation

2008 | A dynamical low-rank approach to the chemical master equation | T. Jahnke, and W. Huisinga
Zeitschrift: Bull. Math. Biol. Seiten: 2283-2302 Band: 70 Link zur Publikation

2008 | Adaptive discrete Galerkin methods applied to the chemical master equation | P. Deuflhard, W. Huisinga, T. Jahnke, and M. Wulkow
Zeitschrift: SIAM J. Sci. Comput. Seiten: 2990-3011 Band: 30 Link zur Publikation

2007 | Optimizing Classification of Drug-Drug Interaction Potential for CYP450 Isoenzyme Inhibition Assays in Early Drug Discovery | B.-F. Krippendorff, P. Lienau, A. Reichel, W. Huisinga
Zeitschrift: J Biomol Screen Seiten: 92-99 Band: 12 Link zur Publikation

2007 | Solving the chemical master equation for monomolecular reaction systems analytically | T. Jahnke, W. Huisinga
Zeitschrift: J. Math. Biol. Seiten: 1-26 Band: 54 Link zur Publikation

2007 | Combining Systems Biology with physiologically-based pharmacokinetics to support the understanding of drug effects | M. von Kleist, C. Kloft and W. Huisinga
Zeitschrift: Proceedings of Foundations of Systems Biology in Engeneering FOSBE Seiten: 231-236

2007 | Hybrid stochastic and deterministic simulations of calcium blips | S. Rüdiger, J.W. Shuai, W. Huisinga, Ch. Nagaiah, G. Warnecke, I. Parker, M. Falcke
Zeitschrift: Biophys. J. Seiten: 1847-1857 Band: 93 Link zur Publikation

2007 | Physiologically based pharmacokinetic modelling: A sub-compartmentalized model of tissue distribution | M. von Kleist and W. Huisinga
Zeitschrift: J. Pharmacokinet. Pharmacodyn. Seiten: 789-806 Band: 34 Link zur Publikation

2006 | Computational Physiology | W. Huisinga
Zeitschrift: European Communications in Mathematical and Theoretical Biology, No. 8, January 2006 Seiten: 12-13 Band: 8 Link zur Publikation

2006 | The virtual lab approach to pharmacokinetic: Design principles and concepts | W. Huisinga, R. Telgmann, M. Wulkow
Zeitschrift: Drug Discov Today Seiten: 800-805 Band: 11 Link zur Publikation

2006 | Adaptive Approach for Modelling Variability in Pharmacokinetics | A. Weiße, I. Horenko, and W. Huisinga
Reihe: Lecture Notes in Computer Science Verlag: Springer Buchtitel: 'Computational Life Sciences II', M.R. Berthold, R. Glen, and I. Fischer (Eds.) Seiten: 194-204 Band: 4216 Link zur Publikation

2006 | Software Supported Modelling in Pharmacokinetics | R. Telgmann, M. von Kleist, and W. Huisinga
Reihe: Lecture Notes in Computer Science Verlag: Springer Buchtitel: 'Computational Life Sciences II', M.R. Berthold, R. Glen, and I. Fischer (Eds.) Seiten: 216-225 Band: 4216 Link zur Publikation

2005 | Elevated Internal Exposure of Children in Simulated Acute Inhalation of Volatile Organic Compounds: Effects of Concentration and Duration | K. Abraham, H. Mielke, W. Huisinga, U. Gundert-Remy
Zeitschrift: Arch Toxicol Seiten: 63-73 Band: 79 Link zur Publikation

2005 | Elevated Internal Exposure of Children in Simulated Acute Inhalation of Volatile Organic Compounds: Dependency on Properties of the Chemical | K. Abraham, H. Mielke, W. Huisinga, U. Gundert-Remy
Zeitschrift: Basic & Clinical Pharmacology & Toxicology Seiten: 242–243 Band: 96 Link zur Publikation

2005 | Adaptive Approach for Non-Linear Sensitivity Analysis of Reaction Kinetics | I. Horenko, S. Lorenz, C. Schütte, W. Huisinga
Zeitschrift: J. Comp. Chem. Seiten: 941-948 Band: 26 Link zur Publikation

2005 | Metastability and Dominant Eigenvalues of Transfer Operators | W. Huisinga, B. Schmidt
Reihe: Lecture Notes in Computational Science and Engineering Verlag: Springer Buchtitel: 'Advances in Algorithms for Macromolecular Simulation', C. Chipot, R. Elber, A. Laaksonen, B. Leimkuhler, A. Mark, T. Schlick, C. Schütte, and R. Skeel (Eds.) Band: 49 Link zur Publikation

2005 | Adaptive simulation of hybrid stochastic and deterministic models for biochemical systems | A. Alfonsi, E. Cances, G. Turinici, B. Di Ventura, W. Huisinga
Zeitschrift: ESAIM: Proc. Seiten: 1-13 Band: 14 Link zur Publikation

2004 | Phase Transitions & Metastability in Markovian and Molecular Systems | W. Huisinga, S. Meyn, Ch. Schütte
Zeitschrift: Ann. Appl. Probab. Seiten: 419-458 Band: 14 Link zur Publikation

2004 | An Averaging Principle for Fast Degrees of Freedom Exhibiting Long-Term Correlations | Ch. Schütte, J. Walter, C. Hartmann, W. Huisinga
Zeitschrift: SIAM Multiscale Modeling and Simulation 2 Seiten: 501-526 Link zur Publikation

2003 | Biomolecular Conformations can be Identified as Metastable Sets of Molecular Dynamics | Ch. Schütte, W. Huisinga
Buchtitel: 'Handbook of Numerical Analysis' edited by P. G. Ciarlet, Special Volume: Computational Chemistry (Vol X) , guest editor C. Le Bris Link zur Publikation

2003 | Extracting Macroscopic Stochastic Dynamics: Model Problems | W. Huisinga, Ch. Schütte, A. M. Stuart
Zeitschrift: Comm. Pure Appl. Math. Seiten: 234-269 Band: 56 Link zur Publikation

2003 | Metastability of Diffusion Processes | Ch. Schütte, W. Huisinga, S. Meyn
Buchtitel: Proceeding of the IUTAM Symposium on Nonlinear Stochastic Dynamics (August 26 - August 30, 2002, Illinois/USA) Link zur Publikation

2001 | Transfer Operator Approach to Conformational Dynamics in Biomolecular Systems | Ch. Schütte, W. Huisinga, P. Deuflhard
Buchtitel: 'Ergodic Theory, Analysis, and Efficient Simulation of Dynamical Systems' edited by B. Fiedler Seiten: 191-223 Link zur Publikation

2000 | Identification of Almost Invariant Aggregates in Reversible Nearly Uncoupled Markov Chains | P. Deuflhard, W. Huisinga, A. Fischer, Ch. Schütte
Zeitschrift: Lin. Alg. Appl. Seiten: 39-59 Band: 315 Link zur Publikation

2000 | On Conformational Dynamics induced by Langevin Processes | Ch. Schütte, W. Huisinga
Buchtitel: 'International Conference on Differential Equations (EquaDiff 99)', edited by B. Fiedler K. Gröger and J. Sprekels, Vol.2 (2000) Seiten: 1247-1262 Link zur Publikation

2000 | Self-Organizing Maps Combined with Eigenmode Analysis for Automated Cluster Identification | T. Galliat, Wilhelm Huisinga, P. Deuflhard
Verlag: Academic Press Buchtitel: 'Neural Computation' edited by H. Bothe and R. Rojas, ICSC Seiten: 227-232 Link zum Preprint

2000 | Biomolecular Conformations as Metastable Sets of Markov Chains | Ch. Schütte, W. Huisinga
Buchtitel: Proceedings of the 38th. Annual Allerton Conference on Communication, Control, and Computing, Oct. 4-6, Allerton House, Monticello, Illinoins/USA (2000) Seiten: 1106-1115 Link zur Publikation

1999 | Faber and Newton Polynomial Integrators for Open-System Density Matrix Propagation | W. Huisinga, L. Pesce, R. Kosloff, P. Saalfrank
Zeitschrift: J. Chem. Phys. Seiten: 5538-5547 Band: 110 Link zur Publikation

1999 | A Direct Approach to Conformational Dynamics based on Hybrid Monte Carlo | Ch. Schütte, A. Fischer, W. Huisinga, P. Deuflhard
Zeitschrift: J. Comp. Phys. Seiten: 146-168 Band: 151 Link zur Publikation

1999 | From Simulation Data to Conformational Ensembles: Structure and Dynamics based Methods | W. Huisinga, Ch. Best, R. Roitzsch, Ch. Schütte, F. Cordes
Zeitschrift: J. Comp. Chem. Seiten: 1760-1774 Band: 20 Link zur Publikation